BMC Medicine2021
A nomogram for combination-therapy benefit in EGFR-mutant NSCLC.
Related service: Statistical analysis and predictive modeling
SELECTED COLLABORATION
Selected Publications
From computational signal to translational evidence: the PLT012 anti-CD36 antibody study in Cancer Discovery 2025 and other co-authored work.
SELECTED COLLABORATION
From computational signal to translational evidence
Selected publications co-authored by our team members. For each one, we list only the computational and analytical contribution.
IF 29.5 (JCR 2025; subject to the journal's official figure)
PLT012, a humanized anti-CD36 antibody, to release anti-tumor immunity in liver cancer and liver metastasis
Background
PLT012 is a humanized anti-CD36 antibody. The study set out to release suppressed anti-tumor immunity in liver cancer and liver metastasis. Our partner was a Swiss clinical-stage immunotherapy startup, and the paper is co-authored.
Computational contribution
The author contributions credit L.-T. Chiu with data curation, formal analysis and methodology.
The authors' contribution was on the computational side: curating and analyzing signals from public data, and connecting them with preclinical and human HCC ex vivo results into one mechanistic line of evidence.
Methods
- TCGA pan-cancer: public tumor molecular data across cancer types.
- CIBERSORT: estimates the proportions of immune cell types in a tissue from expression data.
- scRNA-seq: expression analysis at single-cell resolution.
- GSEA (gene set enrichment analysis): tests whether a set of functionally related genes shifts up or down together.
- Combined with preclinical studies and ex vivo validation in human HCC (hepatocellular carcinoma).
Why it matters
The study supported proof of concept for CD36-targeted immunotherapy. For our partner, the value went beyond a paper: it is mechanistic evidence a third party can check, where computational signals from public data line up with experimental validation.
Advanced Science2020
Dynamic ctDNA neoantigen monitoring, with molecular response detected before imaging response.
Related service: Single-cell and multi-omics integration
Note
Journal impact factors are taken from JCR 2025 and are subject to the journal's official figures.
Need to explain a mechanism to someone outside your team?
Fundraising, licensing and publication all call for mechanistic evidence that holds up to questions.